A Spanish Public Research Institution is offering licences this invention that deals with healthy products obtained by enzymatic hydrolysis of milk proteins. These healthy peptides (small proteins) are nutraceutic/functional food that joins food with therapeutic activity. The peptides have antihypertensive, antioxidant and/or antimicrobial activity. The nutraceutical patented products as hydrolysate or purified bioactive peptides are attractive both for food and pharmaceutical industry.
DESCRIPTIONThe present invention deals with the production of food ingredients containing bioactive peptides with antihypertensive, antioxidant and/or antimicrobial activity. These bioactive peptides are formed by enzymatic hydrolysis of egg white proteins. The bioactive peptides are produced through hydrolysis of one or more proteins, peptides of fragments thereof, comprising the amino acid sequence of said bioactive peptides (preferably caseinates). In a preferred embodiment of the invention the protein or proteins are enzymatically digested with pepsin but any enzyme and hydrolysis conditions that allow breakdown of the protein sequence at the desired peptide bonds may be used. Alternatively, these bioactive peptides can also be produced by other methods, such as chemical synthesis, recombinant production, etc. Said peptides may be consumed as such, in the form of the crude hydrolysates, concentrates of low molecular weight or other active sub fractions obtained by size separation methods or chromatographic methods. Said active hydrolysates, their fractions or the purified peptides can be employed in food products or pharmaceutical formula. In this way, these products might be used in the prevention and treatment of several pathologies, particularly in blood pressure regulation. This invention increases the applications of milk proteins, contributes to their upgrading and favours more profitable uses from an economic point of view.INNOVATIVE ASPECTSThis invention reports for the first time the antihypertensive, antimicrobial and antioxidant activity of the identified peptide sequences. These peptides can be produced by enzymatic hydrolysis with food-grade enzymes of caseinates or derivatives thereof, that is, a cheap and broadly available substrate to be used as an ingredient for functional products.COMPETITIVE ADVANTAGESThe present invention would allow finding new uses to milk caseinates in order to exploit the outputs even beyond their traditional food value, including biomedicals and nutraceuticals. This would contribute to the development of healthy and safe, high-quality products. In this respect, low-cost nitrogen fractions that are obtained by the dairy industry, such as milk caseins and caseinates, could be used in the way described in the present invention to give rise to products with a higher added-value.KEYWORDSBioactive peptides, milk caseinates, angiotensin-converting enzyme inhibitory activity, antihypertensive activity, antioxidant activity, antimicrobial activity. 008001002 Food additives/ Ingredients 008001004 Food Processing 008003 Nutrition and Health 006001016 Pharmaceutical products/Drugs 006001011 Hearth and blood circulation illnessesPATENTPatent applied for at 2005-06-10CONTACTEstrella Marotoemail: e.maroto@orgc.csic.esphone: +34 91 585 52 51 FOR MORE CSIC TECHNOLOGY OFFERS CLICK HERE
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