OTT-CSIC: TECHNOLOGY TRANSFER OFFICE
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The Technology Transfer Office (OTT-CSIC) brings scientific abilities and technological achievements of CSIC to all the Spanish and international economic sectors: companies, public services, etc.

Our principal aim is turning these scientific achievements into economical, cultural and social developments. In order to do this, we:

1. Spread and promote CSIC image and abilities in both social and economical environments.

2. Encourage and make the relationship between our researchers and the different profitable sectors much easier.

3. Stimulate the creation of technological companies within CSIC environment.

Nowadays
Valorisation of wastes from vegetable handling: Obtention of bioactive compounds and dietary fibre. :
Center of Edafology and applied Biology of Murcia of CSIC Spanish Research Group has developed a method for the extraction of bioactive compounds present in the subproducts of the vegetable processing industries. The method is simple and not expensive. By this method extracts enriched in bioactive compounds could be obtained, especially antioxidant...
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Use of carbonate-rich or calcium and magnesium oxide-rich industrial by-products for in situ heavy metals retention :
Center for Environmental Sciences of CSIC licenses a patent useful to remediation of soil and water pollution processes. The carbonate-rich or calcium and magnesium oxide-rich industrial by-products, such as dolomitic residue and sugar foam, can be used for heavy metals retention for prevention of pollution processes and reclamation of contaminat...
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Use of gypsum-rich industrial by-products for in situ heavy metals retention :
Center for Environmental Sciences of CSIC licenses a patent useful to remediation of soil and water pollution processes. The gypsum-rich industrial by-products, such as phosphogypsum and red gypsum, can be used for heavy metals retention and for both prevention of pollution processes and reclamation of contaminated materials. This invention can be...
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Use of JNK protein to control cisplatin-resistant tumoral cells :
The present invention indicates that induction of JNK protein by blocking CL100 and h-VH5 phosphatases allows to overcome cisplatin-resistant tumoral cells and promotes subsequent apoptosis. CL100 and h-VH5 have been identified as targets for optimizing cisplatin therapy.
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Use Of The MAL Protein As New Tumor Marker :
The offer is made by INSTO. BIOLOGIA MOLECULAR ELADIO VIÑUELA. The invention deals with the detection of a new protein as a marker for the characterization of epithelial tumors and other human pathologies, with the advantage that markers for this type of process are not so far widely used. We seek for a company leader in the biodiagnostic field for...
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Utilisation Of Industrial Metal Waste As A Building Material :
National Center for Metallurgical Research of CSIC has developed a process for the utilisation of industrial metal waste. Several wastes coming from different industrial processes of metal production (red mud, from Al industry, jarosites, from zinc industry, etc.) can be used jointly with dust steel powders and dump ferrous slags to produce new bui...
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System for three-dimensional localization and drawing of unearthed finds in paleo-archaeological sites using a network of acoustic sensors :
A team of scientists with the Spain National Research Council has invented and developed an acoustic system to localize and draw objects, remains and fossils in archaeological excavations. It consists of a sensor network and a mobile device to be positioned over the object of interest. The researchers team is looking for a company to license that...
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New yeast strains improving sensorial and technological properties of the white, rose, red and sparkling wines :
Spanish Research Institute has patented a new recombinant industrial wine yeast strain and the method to obtain it. This method allows increasing mannoprotein secretion by the modified strains; as well as improving sensorial and technological properties of the wine fermented by these strains. The Institute is looking for Industrial Partners to lic...
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Non-invasive device for determination of temperature and ice content in frozen food :
A Spanish research institution has patented a new sensor device and non-invasive method for ice content and temperature determination in frozen food. The procedure is based on the application and analysis of low-power ultrasounds and it allows monitorization of frozen food state and optimization of freezing and storage or transport conditions. It ...
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Natural melanins extraction for pharmacologic/cosmetic uses :
Spanish Research Institute has patented the first extraction procedure for the obtaining of natural and unaltered pheomelanin, eumelanin and pseudo-pheomelanin precipitates from feathers and mammal furs. These pigments are the natural skin photoprotector and used as creams would allow the formation of an artificial second skin with different colour...
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METHOD FOR THE IMMOBILIZATION OF A GLUTAMATE DEHYDROGENASE :
Two Spanish Research Institutes have developed a new method for the immobilization of a glutamate dehydrogenase from Thermus thermophilus. The enzyme preparation obtained is extremely stable under a wide range of conditions (e.g., pH 4-10), using NADP(H) and NAD(H) with good activities. It is suitable as a cofactor-regenerator enzyme in oxidation a...
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Environmentally friendly slow release formulations of pesticides :
An Andalusian research group, from a research public institution, has developed a system for controlled release of pesticide in agricultural applications. These formulations are suitable for any type of pesticide independently of its nature (hydrophobic, acidic or basic). These formulations minimize the undesirable losses of the active ingredient t...
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Antibody detector of active DGKalfa protein (in vivo and in vitro) for the diagnostic of autoimmune diseases, leukaemia and Hodking and non-Hodking lymphoma :

A CSIC research group with the UAM and the Biosignal Research Center Kobe of Japan, have developed an antibody able to detect the expression of the DGKalfa active enzyme in screening assays, able to diagnostic autoimmune diseases and lynphoproliferative alterations like leukaemia and Hodking and non-Hodking lymphoma. We are looking for licence o...
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Method and equipment to debitter table olives and obtained product :
Spanish Research Institute has patented a new table olive obtaining method in which sodium hydroxide is not required in the fruit debittering step. Thanks to this non chemical requirement, this procedure can be used to the elaboration of both organic table olives and olives in brine. Our interest is now focused on the industrial development of thi...
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Therapeutic use of the ability of glycoprotein G from herpes simplex virus to induce cell migration :
The gG protein from herpes simplex virus (HSV) interacts with chemokines, important immune mediators, and promotes their ability to induce migration of immune cells into tissues. The gG protein will be useful to treat human diseases characterized by altered migration of immune cells. In addition, the blockade of the gG function may inhibit the infe...
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Compounds that induce telomerase activity and its application on dyskeratosis congenita, premature aging syndromes and other pathologies :
A Spanish Research Institute patented new compounds that induce telomerase activity, useful for the treatment of diseases with telomerase activity alterations and cellular senescence, such as premature aging syndromes, dyskeratosis congenita, neurodegenerative diseases, cancer and other pathologies. We look for companies interested in the licens...
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Removal of petrol from sunken oil tanker by using supercritical fluids :
A Spanish research institute has patented a new method for the removal of petrol from sunken oil tankers to the water surface by using supercritical fluids in the conditions presented at such depths. The process has clear economical advantages over existing methods for the extraction of petrol from sunken containers avoiding environmental disasters...
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Procedure to obtain Fresh-cut Artichokes without sulfites :
A research group from a Spanish public research institute has developed a technology to obtain Fresh-Cut Artichokes without sulfites. The procedure combines physical methods with natural chemical preservatives to keep the organoleptic, nutritional and microbial quality of fresh-cut artichokes under refrigeration. The technology is cheap and easy to...
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Tissue Engineered Construct For the Repair and Regeneration of (Musculoskeletal) Tissue. :

An Andalusian research group has developed a living tissue engineered construct which can be used for their applications in cell therapy and skeletal surgery interventions. The best advantage of the construct is that cells can be maintained viable and stable in cultivation and that can be differentiated into the appropiate phenotype before impla...
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Pilot plant for plant food treatment and water disinfection with ozone as gas or in aqueous solution. :
A Spanish public research center has a pilot plant optimized for ozone treatment of vegetables as gas or in aqueous solution. This plant allows the research and development of the proper conditions for the application of ozone as gas or in aqueous solution to vegetables as whole or freshly cut products. Ozone is produced in the plant and the proces...
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High through put in vitro methods for determining pharmacokinetic properties (oral absorption and penetration in the central nervous system) of products, including molecules with a limited solubility in water :
A Spanish Research Institute (CSIC) has implemented in vitro methods for the high-throughput evaluation of pharmacokinetic properties (oral absorption and penetration into the central nervous system) of products, including molecules with low aqueous solubility. These methods are a very good alternative to the use of experimental animals and thus, t...
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Method to induce resistance against Cucurbit yellow stunting disorder Virus (CYSDV). :
A Spanish research institute has developed a method to induce genetic resistance against Cucurbit yellow stunting disorder virus (CYSDV). This virus causes important economic losses in cucurbits crops and there was no method available to generate resistance against it. The use of the plants obtained by this technology with improved CYSDV genetic re...
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Method of diagnosis for plant parasitic nematodes (Meloidogyne) :
Spanish Public Research Institutions are offering licences of this invention that deals with A procedure of detection for nematodes species such as M. incognita, M. arenaria and M. javanica, considered as important plant pathogens. Detection is based on identification by means of monoclonal antibody of specific proteins of such nematodes species. ...
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New procedure to identify commercial species belonging to the hake family :
A Spanish research group offers a new mass spectrometric procedure, which allows the characterization of the main commercial species of the Merlucciidae family across the complete food chain. This procedure enables the unequivocal identification, in less than two hours, of the species in all type of products and sub-products: fresh, refrigerated, f...
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Non-invasive ultrasonic technology for selective isolation of certain sub-populations of particles in poly-disperse suspensions :

Utility: it is a mew mehtod for isolation-extraction of cells/microorganisms or particles in suspensión

Advantages:

1.      It is a non invasive tech. that does not require the introduction of extern nanoparticles to drive-separate the cells to be extracted.

2.     ...
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LOW COST CATALYTIC BRIQUETTES FOR NOx REDUCTION :
Spanish Research Institute has patented a new method for the preparation of low cost catalytic briquettes for the reduction of NOx. Catalytic briquettes can be prepared using petroleum coke ashes. They are efficient even at low temperatures and have low pressure drop and an easy elaboration procedure. These features make the product interesting for...
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Sulphated vanadium catalyst supported on carbon coated monoliths with optimised properties for the selective catalytic reduction of NO at low temperature :
Spanish Research Institute has patented a new catalyst with enhanced features for the selective catalytic reduction of NOx at low temperature. It is aimed to be installed in a tail end configuration in power plants, engines, turbines…and all the combustion plants that need to reduce the NOx emissions. These features make the product interesting for...
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New Procedure for the manufacture of fermented milks with high contents of prebiotics. :
Spanish Research Institute has patented a new method for the manufacture of fermented milks with a high content of prebiotic carbohydrates formed during the manufacturing process. This provides added value to the final product. The Institute is looking for Industrial Partners to development of such a procedure and license agreement.
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Synthesis gas production from CH4 and CO2 rich gases using microwave heating and carbon-based catalysts. :
A Spanish Research Institute has patented a new method to obtain synthesis gas from CH4 and CO2 rich gases, like biogas. The advantages are that the process do not requires of steam generation, does not use any other external oxidant agent and does not use metallic-based catalyst. The main interest is the industrial development of this process. Thu...
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Ionic exchange membranas for Proton Exchange Membrane Fuel Cells (PEMFC) prepared from natural rubber latexes :
A new family of hybrid membranes (organic-inorganic) with proton conductivity has been developed for a Spanish Research Institute for its application in Proton Exchange Membrane Fuel Cells (PEMFC). They are composed by a polymeric matrix prepared from natural rubber latex loaded with an inorganic compound, which is responsible of its proton conduct...
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Fluorescent miltefosine analogs for diagnosis of infectious diseases :
A Spanish Research Institute has patented new fluorescent miltefosine analogs. The novel compounds were incorporated easily into microorganisms such as fungi, Acanthamoeba and free-living Protozoa, thus allowing their detection and identification by fluorescence microscopy and detection of miltefosine-resistant microorganisms and follow-up of induc...
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A novel approach for the purification of recombinant proteins by affinity chromatography based on a biological solubility enhancer :
A Spanish Research Institute has patented a novel approach for the production and purification by affinity chromatography of recombinant proteins fused with a â-trefoil lectin module. This module can be considered a biological solubility enhancer which additionally functions as an excellent affinity tag. The protocol is both efficient and economica...
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Production of activated carbons from apple-derived wastes for industrial use :
A Spanish Research Institute joined to a Swiss University has patented a new method to produce active carbons at industrial scale.

The Institute is looking for industrial partners related to the production of cider and apple juices, manufacture of active carbons, development of systems for electric energy storage, separation and purificat...
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COMBUSTION METHOD WITH INTEGRATED CAPTURE OF CO2 BY CARBONATION :
A Spanish Research Institute and a British University have patented a new method of combustion with integrated capture of CO2 by carbonation. They are looking for Industrial Partners interested in novel concepts for the separation of CO2 from combustion gases at high temperatures. The method is suited for large-scale stationary sources of CO2.
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A polypeptide protecting against HIV infection :
A Spanish research group has controlled HIV infection in lymphocytes using an extracellular polypeptide homologous to a fragment of a HIV envelope protein. Besides, gene therapy is eased since less than 10% lymphocytes in a cell culture need to be transformed to confer protection to the whole culture. The transformed lymphocytes are functional, rel...
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Approaches to prevent or delay neural synapses loss during aging or in neurodegenerative diseases :
A Spanish research group has found that formation of synapses (communication junctions of nerve cells) is controlled independently of age by PI3K, an enzyme involved in signal transduction. Aging and neurological disorders cause synapses loss, which could be prevented / delayed by increasing synthesis of PI3K (by gene therapy) or by activating it ...
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PROCEDURE FOR THE DIAGNOSIS AND TREATMENT OF DISEASES WITH ALTERATIONS IN p38 KINASE :
A Spanish research institute has developed a new method for the diagnosis of pathologies with alterations in p38 kinase, specifically for autoimmune and inflammatory diseases or tumors, based on flow cytometric detection and quantification of p38 phosphorylation in blood samples. Analysis of more than 200 samples showed that the method is also a g...
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SOLUBLE CAROTENOID AGGREGATE OR CAROTENOID MOLECULAR COMPLEX, OBTENTION PROCEDURE AND APPLICATIONS :
Spanish Research Institute has patented a new method to dissolve oily matrixes, enriched in carotenoid pigments, in water, by creating molecular aggregates that complex the carotenoid fraction, what provides it the solubility in water and a higher both physical and chemical stability, without using a high-cost instrumentation. The product is able t...
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Hydrophilic acrylic copolymers derived from eugenol, preparation, characterization and their use in ophthalmic lenses :
A Spanish Research Institute (Institute of Polymer Science and Technology) has patented the development of hydrophilic copolymeric systems with eugenol derivatives that present transparency and high refractive index. These characteristics make them adequate for their use in ophtalmological lenses, for example intraocular lenses . The Institute i...
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Electrical and reusable device for microarray readout :
Spanish Research Institute has patented a new type of electrical microarray reader for standard microarrays on low-cost substrates as those used in traditional fluorescence microarrays. The reader device can be manually or automatically washed and reused an unlimited number of times. Owing to its row-column transducer access, the development of re...
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Renal fibrosis identification procedure. Use of related compounds on development of pharmaceutical specialities :
A Spanish research group has developed a renal fibrosis identification procedure based on detection of Snail genic family responsible of embryonic kidney development. The invention also includes the possibility to use the Snail transcription factors and their inhibitors in the pharmaceutical specialities. The group is interested in establishing agr...
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Cold and salt tolerant transgenic plant overexpressing RCI5 :
A Spanish Research Institute has patented the use of a new gene to obtain transgenic plants with increased tolerance to cold and salt stress. The gene, named RCI5, encodes an FMO monooxygenase involved in TMAO biosynthesis. The invention also includes the exogenous application of TMAO to increase plant tolerance to these abiotic stresses. The Inst...
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Monomers and acrylic polymers derived from eugenol, formulations and compositions based on these components and their biomedical applications :
A Spanish Research Institute (Institute of Polymer Science and Technology) has patented the development of new self-curing acrylic formulations bearing eugenol derivatives. Various eugenol derivatives susceptible to polymerize and copolymerize with other acrylic monomers have been prepared and incorporated in their monomeric form to the liquid pha...
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CONTINUOUS IN SITU FUNCTIONALLY GRADED SILICON NITRIDE MATERIALS, METHOD FOR MANUFACTURING, PROPERTIES AND THEIR APPLICATIONS :
Spanish Research Institute has sought a patent about a method for manufacturing continuous in situ functionally graded silicon nitride materials from a sole homogenous starting powder. The process can be easily transferred to a mass production and the developed components could be used in technological applications under thermomechanical and tribol...
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Process for controlling the grain growth of polycrystalline alumina :
A Spanish Research Institute has patented a new low-cost method that allows to sinter alfa-alumina at a raised density minimizing the grain growth. This method permits to obtain ultra-hard materials of polycrystalline alumina with a light transmittance superior compared to the the non-treated samples. The Institute is looking for Industrial Partne...
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A new bacterial chitinase with antifungal activity of broad spectrum :
A Spanish Research Institute has patented a new natural biodegradable product to avoid fungal plant pathogen infections in the field and under storage. Potentially applicable in the agro and feed and food sectors and eventually in the plant, animal and human health sectors as well. The Institute is looking for Industrial Partners to lice...
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Olive harvesting machine :
Spanish Research Institutions (CSIC-CITA) offer an invention consisting of an olive harvesting machine designed to perform automatically harvesting olives, specially suitable for small farms or olive farms with little vigorous growth varieties and with a high degree of pliability so that can be transported in a standard measures truck and also has ...
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Screening method of anti-tumoral compounds inhibitors of ERK dimerization :
A Spanish Research Institute has patented a new screening method of anti-tumoral compounds based on the inhibition of ERKs dimerization. Researchs from such institution have recently discovered that the inhibition of ERKs dimerization decreases cellular transformation and tumor progression. We look for companies interested to license the patent ...
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Aerobic bacterial electrode for anode of a fuel cell without redox mediators nor a proton exchange membrane :
Spanish Research Institute has patented a new method to prepare a bacterial electrode that produces electricity from organic substrate without the need of redox mediators. The device is equally efficient under aerobic and anaerobic conditions. It can be used as anode in a membrane-less fuel cell. The Institute is looking for Industrial...
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Process for the preparation of patinas or films for stony surfaces and its applications :
A Spanish Research Institute has patented a new procedure to prepare a protective and decorative patina or film to be applied on stony surfaces. The patina or film resembles the historical patinas found on numerous monuments in Spain and in the Mediterranean Basin. The film is made basically with natural products and can be applied both on monument...
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Technology for the enhancement of the efficiency in solar cells, photodetectors and thermo-photovoltaic devices :
Spanish Research Institute IMM-CSIC has patented a new method based on the use of photonic crystals to enhance the efficiency of solar cells, photodetectors and thermo-photovoltaic devices, enhancing the transmission of light inside the device. Enlargements of the efficiency between 10% and 20% have been measured for the spectral region where the ...
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Micronano devices for in-vivo study of intracellular parameters in cells and tissues. :
A Spanish researchers team offers the fabrication of micronano devices for in-vivo study of (Inglés) A Spanish researchers team offers the fabrication of micronano devices for in-vivo study of intracellular parameters of cells and tissues. The devices can be introduced by microinjection, phagocytosis or lipofection. The fabrication technology ...
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Low carbon microalloyed steels refined by intragranular nucleation of ferrite :
The Spanish research institute has patented a procedure for refining the ferrite grain in microalloyed steels. Unlike classic microalloyed steels, the steels in question have optimised amounts of V additions as a microalloying element and N additions as an element in interstitial solution which precipitate during rolling to form precipitates (VN) a...
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Device for the determination of the porosity in thin films and membranes :
The “Instituto de Ciencia de Materiales de Sevilla” of CSIC (Spain) has Developer a procedure for the determination of porosity in thin films and membranes. It is possible to measure the pore volume, its type and its distribution. Po0ssible applications are the control of the optical properties by exposure to the atmosphere or the determination of ...
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Development of magnesium alloys with high mechanical properties in the Mg-MT-RE system exhibiting superplastic behaviour :
Spanish Research Institute has developed new alloys in the Mg-MT-RE system with high mechanical properties up to 250ºC and susceptible to be superplastically deformed between 300 and 400ºC. The Institute is looking for Industrial Partners interested in test these alloys
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DENSE AND HOMOGENOUS CARBON NANOTUBES/SILICON NITRIDE CERAMIC MATERIALS, METHOD FOR MANUFACTURING AND THEIR APPLICATIONS :
Spanish Research Institute has sought a patent about a method for manufacturing dense and homogeneous carbon nanotubes containing silicon nitride matrix composites. The materials could be used in technological applications under thermomechanical and tribological demanding conditions. The interest is based in the industrial development of that metho...
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Automatic control procedure based on fuzzy logic for drilling processes :
A Spanish Research Institute has patented a new method/system to optimize drilling processes on the basis of a new control system. The proposed control system provides outstanding transient response without overshoot, small rise time and minimum steady-state error. In order to suppress the cutting-force increase, the feed rate is decreased gradu...
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